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Martin A. Weinstock, MD; Silvija Coulter, MS; Jeannie Bates; Hendrik A. Bogaars, MD; Pamela L. Larson, MD; Glenna C. Burmer, MD

Arch Dermatol. 1995;131(6):701-704.

Abstract
Background
Oral psoralen with UV-A (PUVA) photochemotherapy is known to cause cutaneous malignancies and has been associated with cutaneous immunosuppression. Human papillomavirus infection has also been associated with cutaneous malignancies and with immunosuppressed individuals. We therefore sought evidence of human papillomavirus infection in a patient with a long history of PUVA therapy and multiple cutaneous malignancies.

Observations
During a 15-year period, an otherwise healthy patient with psoriasis who had undergone a 10-year course of PUVA photochemotherapy developed 13 squamous cell carcinomas, eight lesions diagnosed as ''squamous cell carcinoma vs keratoacanthoma,'' 14 other keratoacanthomas, six basal cell carcinomas, one melanoma in situ, and 18 other keratinocytic dysplasias. Twenty-two of the 30 lesions tested for human papillomavirus DNA by polymerase chain reaction were positive for type 16/18, including six of the seven basal or squamous cell carcinomas tested.

Conclusion
We hypothesize that PUVA therapy-induced immunosuppression may play an important role in PUVA-related carcinogenesis by affecting the extent and pathogenicity of human papillomavirus infection.

(Arch Dermatol. 1995;131:701-704)

Author Affiliations
From the Dermatoepidemiology Unit, Veterans Affairs and Roger Williams Medical Centers and Brown University, Providence, RI (Drs Weinstock and Larson) and the Departments of Pathology, Roger Williams Medical Center and Brown University (Dr Bogaars) and University of Washington, Seattle (Mss Coulter and Bates and Dr Burmer). Dr Larson is now in private practice in Rochester, NY.

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