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An Immunohistochemical and In Situ Hybridization Study

Omar P. Sangüeza, MD; Jenny Galloway, MD; Phyllis A. Eagan, MT(ASCP); Rita M. Braziel, MD; Margaret L. Gulley, MD

Arch Dermatol. 1996;132(3):279-282.

Abstract
Background and Design
Lymphomatoid papulosis (LyP) and cutaneous Hodgkin's disease share many clinical, histopathologic, and immunohistochemical features. Epstein-Barr virus (EBV) has been implicated in the pathogenesis of several lymphoid malignancies, including Hodgkin's disease. Given the similarities between LyP and Hodgkin's disease, we asked if EBV could be detected in lesions of LyP. We examined 31 specimens of LyP that were obtained from 24 patients for evidence of EBV by in situ hybridization to EBER1 transcripts and for immunohistochemistry of viral latent membrane protein 1 (LMP1).

Results
In no instance was there any evidence of EBV gene products by either in situ hybridization or immunohisto-chemistry.

Conclusions
The absence of EBV in LyP suggests that this virus is not operative in the pathogenesis of LyP. Furthermore, it suggests that LyP and Hodgkin's disease may not share the same molecular mechanisms despite their phenotypic similarities.

(Arch Dermatol. 1996;132:279-282)

Author Affiliations
From the Departments of Pathology and Medicine, Division of Dermatology, Medical College of Georgia, Augusta (Dr Sangüeza); the Department of Pathology, Oregon Health Sciences University, Portland (Drs Galloway and Braziel); and the Department of Pathology, University of Texas Health Science Center at San Antonio, Audie L. Murphy Veterans Affairs Hospital (Ms Eagan and Dr Gulley).

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