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Long-term Follow-up of Non-HIV Kaposi's Sarcoma Treated With Low-Dose Recombinant Interferon Alfa-2b
Claudia S. Costa da Cunha, MD;
Céleste Lebbé, MD, PhD;
Michel Rybojad, MD;
Félix Agbalika, MD;
Françoise Ferchal, MD;
Claire Rabian, MD;
Marie D. Vignon-Pennamen, MD;
Fabien Calvo, MD, PhD;
Patrice Morel, MD
Arch Dermatol. 1996;132(3):285-290.
Abstract
Background and Design
We reviewed the follow-up of 16 patients with Kaposi's sarcoma not related to human immunodeficiency virus (13 with classic Kaposi's sarcoma and three with endemic Kaposi's sarcoma; median age, 58 years) treated by low-dose recombinant interferon alfa-2b (5 million U three times weekly for at least 6 months).
Results
One patient had a complete response, nine had a major response, three had stable disease, and one had a minor response. Visceral disease stabilized and symptoms improved in three patients. Limited relapse was noted in four patients after withdrawal of interferon.
Conclusion
Our results confirm the efficacy and safety of low-dose recombinant interferon alfa-2b in the longterm treatment of both cutaneous and visceral lesions of Kaposi's sarcoma not related to human immunodeficiency virus.
(Arch Dermatol. 1996;132:285-290)
Author Affiliations
From the Departments of Dermatology (Drs Costa da Cunha, Lebbé, Rybojad, and Morel), Virology (Drs Agbalika and Ferchal), Immunology (Dr Rabian), and Histology (Dr Vignon-Pennamen) and Laboratory of Pharmacology (Dr Calvo), Hôpital Saint Louis, Paris, France.
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