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Evidence for Eosinophil Protein Deposition

Sélim Aractingi, MD; Anne Janin, MD; Jean Marc Zini, MD; Marie Sophie Gauthier, MD; Laurence Chauvenet, MD; Gérard Tobelem; Lionel Prin, MD; Olivier Chosidow, MD; Camille Frances, MD

Arch Dermatol. 1996;132(5):535-541.

Abstract
Background
Mucosal erosions can be a presenting feature of the hypereosinophilic syndrome. The aim of this study was to analyze in situ the presence of eosinophil proteins and the state of eosinophil activation. Biopsy specimens of mucosal lesions and normal skin were taken from two men with oral and genital erosions typical of hypereosinophilic syndrome. Tissue sections were immunohistochemically labeled with anti-major basic protein, anti—eosinophil-derived neurotoxin, and anti—eosinophil peroxidase antibodies. The same specimens were also subjected to electron microscope examination.

Observations
Eroded specimens displayed areas of eosinophil spongiosis within which extracellular deposits of eosinophil peroxidase, major basic protein, and eosinophil-derived neurotoxin were present. In normal skin, only a few eosinophils were present within the capillary lumen, and no extracellular deposits of these proteins were seen. Under the electron microscope, the cytoplasmic membranes of eosinophils located around the erosion were disrupted. Remnants of necrotic keratinocytes were found near these lysed eosinophils.

Conclusion
As with other involved organs in hypereosinophilic syndrome, mucosal erosions seem to be the consequence of eosinophil protein release.

(Arch Dermatol. 1996;132:535-541)

Author Affiliations
From Unité de dermatologie, Hôpital Tenon, Paris, France (Drs Aractingi and Gauthier); Service d'anatomie-pathologique C, Hôpital Calmette, Lille, France (Dr Janin); Service d'angio-hématologie, Hôpital Lariboisière, Paris (Dr Zini and Mr Tobelem); Service de médecine interne, Hôpital Hôtel Dieu, Paris (Dr Chauvenet); Institut Pasteur de Lille (Dr Prin); and Service de médecine interne, Groupe Hospitalier Pitié-Salpêtrière, Paris (Drs Chosidow and Frances).

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