 |
|
Does Estrogen Prevent Skin Aging?Results From the First National Health and Nutrition Examination Survey (NHANES I)
Laura B. Dunn, AB;
Mark Damesyn, MPH;
Alison A. Moore, MD;
David B. Reuben, MD;
Gail A. Greendale, MD
Arch Dermatol. 1997;133(3):339-342.
Abstract
| |
Objective
To evaluate the relation between noncontraceptive estrogen use and skin wrinkling, dryness, and atrophy.
Design
Cross-sectional analysis of a national probability sample-based cohort study.
Setting
Multiple community sites throughout the United States.
Participants
Postmenopausal women (n=3875) aged 40 years and older at baseline.
Measurements
Skin conditions (wrinkling, dryness, and atrophy) were ascertained using a uniform clinical examination by trained dermatology resident physicians. Self-reported use of estrogen before the baseline examination, sunlight exposure, and smoking history were obtained by standardized interview. Body mass index, a measure of weight in kilograms divided by the square of the height in meters, was evaluated in uniform examination clothing.
Results
Mean (±SD) age of the participants was 61.6 (±9.0) years and mean (±SD) number of years since menopause was 15.6 (±9.4). Most were white (83.7%), the remainder being African American (15.9%) or another race (0.4%). Atrophy was present in 499 (16.2%), dry skin in 1132 (36.2%), and wrinkled skin in 880 women (28.2%). The prevalence of all 3 skin conditions was lower in African American women compared with white women. Information on hormone use was available for 3403 participants (88%). Among all women, after adjustment for age, body mass index, and sunlight exposure, estrogen use was associated with a statistically significant decrease in the likelihood of senile dry skin (odds ratio, 0.76; 95% confidence interval, 0.60-0.97). The odds of wrinkling were substantially lower in estrogen users, adjusted for age, body mass index, and sun exposure (odds ratio, 0.68; 95% confidence interval, 0.52-0.89) and additionally for smoking (odds ratio, 0.67; 95% confidence interval, 0.44-1.01). In multivariable models, estrogen use was not associated with skin atrophy.
Conclusion
These results strongly suggest that estrogen use prevents dry skin and skin wrinkling, thus extending the potential benefits of postmenopausal estrogen therapy to include protection against selected ageand menopause-associated dermatologic conditions.
Arch Dermatol. 1997;133:339-342
Author Affiliations
From the University of California at San Francisco, School of Medicine (Ms Dunn); UCLA School of Public Health (Mr Damesyn) and Division of Geriatrics, UCLA School of Medicine (Drs Moore, Reuben, and Greendale), Los Angeles, Calif.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Induction of Collagen by Estradiol: Difference Between Sun-Protected and Photodamaged Human Skin In Vivo
Rittie et al.
Arch Dermatol 2008;144:1129-1140.
ABSTRACT
| FULL TEXT
Dietary nutrient intakes and skin-aging appearance among middle-aged American women
Cosgrove et al.
Am. J. Clin. Nutr. 2007;86:1225-1231.
ABSTRACT
| FULL TEXT
Medroxyprogesterone Acetate Antagonizes the Effects of Estrogen Treatment on Social and Sexual Behavior in Female Macaques
Pazol et al.
J. Clin. Endocrinol. Metab. 2004;89:2998-3006.
ABSTRACT
| FULL TEXT
Treatment of Photoaging
Stern
NEJM 2004;350:1526-1534.
FULL TEXT
Prescribing Hormone Replacement Therapy for Menopausal Symptoms
McNagny
ANN INTERN MED 1999;131:605-616.
ABSTRACT
| FULL TEXT
Use of Hormone Replacement Therapy by Postmenopausal Women in the United States
Keating et al.
ANN INTERN MED 1999;130:545-553.
ABSTRACT
| FULL TEXT
Estrogen, Skin Aging, and Study Design
Whitmore
Arch Dermatol 1997;133:1460-1461.
ABSTRACT
A New Wrinkle on Estrogen Benefits?
JWatch Women's Health 1997;1997:7-7.
FULL TEXT
Does Estrogen Prevent Skin Aging?
Journal Watch Dermatology 1997;1997:8-8.
FULL TEXT
|
