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Increased Scalp Skin and Serum 5 -Reductase Reduced Androgens in a Man Relevant to the Acquired Progressive Kinky Hair Disorder and Developing Androgenetic Alopecia
Philippe Boudou, PhD;
Pascal Reygagne, MD
Arch Dermatol. 1997;133(9):1129-1133.
Abstract
Background
The acquired progressive kinking of scalp hair is a disorder in which affected hairs resemble secondary sexual hairs. Some authors have evoked an androgen-related disorder that heralds the onset of androgenetic alopecia. To verify this hypothesis, we focused our attention on a 23-year-old man who has this unusual disorder, which is progressing toward androgenetic alopecia. Patient's circulating 5 -reductase reduced androgen levels; scalp skin 5-dihydrotestosterone formation; and trichography, histological, scanning, and polarizing electron microscopy analyses were compared in normal and affected scalp skin areas.
Observations
Results of histological and scalp skin 5-dihydrotestosterone formation analyses and comparison of growth pattern of kinky hair in the affected areas with that of healthy hair were similar to those found in androgenetic alopecia.
Conclusions
No data are available to confirm the presence of a sole entity, even if our arguments support our hypothesis. The confirmation of this tendency warrants further investigation.
Arch Dermatol. 1997;133:1129-1133
Author Affiliations
From the Departments of Hormonal Biology (Dr Boudou) and Dermatology (Dr Reygagne) and the Sabouraud Hair Research Center (Dr Reygagne), Saint-Louis University Hospital, Paris, France.
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