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Epiluminescence Microscopy for the Diagnosis of Doubtful Melanocytic Skin Lesions
Comparison of the ABCD Rule of Dermatoscopy and a New 7-Point Checklist Based on Pattern Analysis
Giuseppe Argenziano, MD;
Gabriella Fabbrocini, MD;
Paolo Carli, MD;
Vincenzo De Giorgi, MD;
Elena Sammarco, MD;
Mario Delfino, MD
Arch Dermatol. 1998;134:1563-1570.
Objective To compare the reliability of a new 7-point checklist based on simplified epiluminescence microscopy (ELM) pattern analysis with the ABCD rule of dermatoscopy and standard pattern analysis for the diagnosis of clinically doubtful melanocytic skin lesions.
Design In a blind study, ELM images of 342 histologically proven melanocytic skin lesions were evaluated for the presence of 7 standard criteria that we called the "ELM 7-point checklist." For each lesion, "overall" and "ABCD scored" diagnoses were recorded. From a training set of 57 melanomas and 139 atypical non-melanomas, odds ratios were calculated to create a simple diagnostic model based on identification of major and minor criteria for the "7-point scored" diagnosis. A test set of 60 melanomas and 86 atypical non-melanomas was used for model validation and was then presented to 2 less experienced ELM observers, who recorded the ABCD and 7-point scored diagnoses.
Settings University medical centers.
Patients A sample of patients with excised melanocytic lesions.
Main Outcome Measures Sensitivity, specificity, and accuracy of the models for diagnosing melanoma.
Results From the total combined sets, the 7-point checklist gave a sensitivity of 95% and a specificity of 75% compared with 85% sensitivity and 66% specificity using the ABCD rule and 91% sensitivity and 90% specificity using standard pattern analysis (overall ELM diagnosis). Compared with the ABCD rule, the 7-point method allowed less experienced observers to obtain higher diagnostic accuracy values.
Conclusions The ELM 7-point checklist provides a simplification of standard pattern analysis because of the low number of features to identify and the scoring diagnostic system. As with the ABCD rule, it can be easily learned and easily applied and has proven to be reliable in diagnosing melanoma.
From the Departments of Dermatology (Drs Argenziano, Sammarco, and Delfino) and Molecular and Cellular Biology and Pathology (Dr Fabbrocini), Federico II University of Naples, Naples, and the Department of Dermatology, University of Florence, Florence (Drs Carli and De Giorgi), Italy.
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