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Janine Wechsler, MD; Rein Willemze, MD; Adrian van der Brule, MD; Elisabeth Thomine, MD; Pascal Joly, MD; Olivier Verola, MD; Yvette Fonck, MD; Pierre Souteyrand, MD; Marie-Hélène Delfau, MD; Martine Bagot, MD; Philippe Gaulard, MD; for the French Study Group of Cutaneous Lymphomas

Arch Dermatol. 1998;134:479-484.

Background  Epstein-Barr virus (EBV) has been demonstrated in angiocentric immunoproliferative lesions, suggesting that it could be a causative factor. We investigated for the presence of EBV in 12 primary and 2 secondary cutaneous angiocentric lymphomas (CALs).

Observations  In the 2 secondary CALs, strong reactivity for EBV RNAs and latent membrane protein 1 were detected on paraffin-embedded sections. In contrast, 10 of 12 primary CALs were completely negative for EBV RNAs and latent membrane protein 1. In 2 primary CALs, EBV RNAs and latent membrane protein 1 were detected in few tumor cells. In the group of primary CALs, 8 of 12 were still alive at last follow-up, 3 died of systemic lymphoma, and 1 died of another cause, whereas both patients with secondary CALs died of disease within 1 year.

Conclusion  Differences in the presence of EBV and clinical behavior between primary and secondary CALs suggest that different mechanisms are operative in the pathogenesis of these conditions, and indicate that the 2 groups should be considered separately.

From the Departments of Pathology (Drs Wechsler and Gaulard), Immunology (Dr Delfau), and Dermatology (Dr Bagot), Hôpital Henri-Mondor, Créteil, France; Departments of Dermatology (Dr Willemze) and Pathology (Dr van der Brule), Free University Hospital, Amsterdam, the Netherlands; Departments of Pathology (Dr Thomine) and Dermatology (Dr Joly), Hôpital Charles-Nicolle, Rouen, France; Department of Pathology, Hôpital Saint-Louis, Paris, France (Dr Verola); and Departments of Pathology (Dr Fonck) and Dermatology (Dr Souteyrand), Centre Hospitals-Universitaire (CHU) de Clermont-Ferrand, France.

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