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M. Birgette Maessen-Visch, MD; Karly Hamulyak, PhD, MD; Dignus J. Tazelaar, MD; Nico H. C. M. N. Crombag, MD; H. A. Martino Neumann, PhD, MD

Arch Dermatol. 1999;135:41-44.

Objectives  To study the prevalence of factor V Leiden mutation in patients with chronic venous insufficiency and venous leg ulcers, compared with a control group, and to find out whether factor V Leiden mutation is more frequent in patients with chronic venous insufficiency and a history of deep venous thrombosis.

Design  A case control study.

Setting  Three outpatient dermatological clinics.

Patients  Ninety-two patients (37 men, 55 women) with venous leg ulcers and 53 control patients (23 men, 30 women).

Main Outcome Measure  Factor V Leiden mutation.

Results  Factor V Leiden mutation was significantly more frequent in patients with chronic venous insufficiency and venous leg ulcers than in the control group (23% vs 7.5%; P=.03), and the patients with factor V Leiden mutation were more likely to have a history of venous thromboembolism (91% vs 48%, P=.002). Also, recurrent deep venous thrombosis (38% vs 14%) and recurrent leg ulcerations (9 episodes or more) occurred more frequently in the patients with factor V Leiden mutation (43% vs 19%, P=.01). No difference was observed in venous refill time or in the presence of dermatoliposclerosis and atrophie blanche.

Conclusions  Factor V Leiden mutation is more frequent in patients with venous leg ulceration than in the control group and the general population. Patients with factor V Leiden mutation have an increased risk of developing deep venous thrombosis and recurrent leg ulceration.

From the Departments of Dermatology (Drs Maessen-Visch and Neumann) and Hematology (Dr Hamulyak), University Hospital Maastricht, Maastricht, and the Departments of Dermatology, Ziekenhuis De Tjongerschans, Heerenveen (Dr Tazelaar), and Canisius Wilhelmina Ziekenhuis, Nijmegen (Dr Crombag), the Netherlands.

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