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Gil Yosipovitch, MD; Baruch Mevorah, MD; Michael David, MD; Maora Feinmesser, MD; Emmilia Hodak, MD; Boaz Gabay, MD; Jamal Ammash, MD; Peter M. Elias, MD

Arch Dermatol. 1999;135:1237-1242.

Background  In addition to the well-defined hereditary primary ichthyoses, many sporadic or less well-defined keratinization disorders with or without systemic manifestations have been reported. Herein we describe ichthyosiform dermatosis associated with type 2 diabetes mellitus.

Observations  The patients were members of a large Arab family with heavy consanguinity. Eighteen members were affected with a variously severe scaly disorder. They showed migratory polycyclic keratotic scaly plaques evolving into diffuse generalized scaling or complete remission. Acanthosis nigricans–like lesions were also noted, and there was an association with type 2 diabetes mellitus. A scarcity of intercorneocyte lamellae and reduction in lamellar body contents were observed.

Conclusions  We could not find a report of a similar dermatosis. Furthermore, an association between ichthyosis and diabetes has not been documented. Therefore, we believe that this may constitute a new entity.

From the Departments of Dermatology (Drs Yosipovitch, David, Hodak, and Gabay) and Institute of Pathology (Dr Feinmesser), Rabin Medical Center, Petah Tiqva, Israel; Elias Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv, Israel (Drs Yosipovitch, Mevorah, David, Feinmesser, Hodak, and Gabay); Kupat–Hulim Clalit Gissar, Azarka, Israel (Dr Ammash); and Department of Dermatology, Veterans Affairs Medical Center, University of California, San Francisco (Dr Elias).

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