 |
|
Oral Crohn Disease
Clinical Characteristics and Long-term Follow-up of 9 Cases
Alain Dupuy, MD;
Jacques Cosnes, MD;
Jean Revuz, MD;
Jean-Charles Delchier, MD;
Jean Pierre Gendre, MD;
Anne Cosnes, MD
Arch Dermatol. 1999;135:439-442.
Background Oral localization of Crohn disease is uncommon and must be differentiated from nonspecific lesions. Its natural course and its long-term prognosis are unknown.
Observations We studied 9 patients (8 male, 1 female; age range, 7-52 years; median age, 16 years) with Crohn disease and specific oral lesions, including deep linear ulcers, pseudopolyps, and/or labial or buccal swelling and induration. The prevalence of such lesions was 0.5%. The median follow-up was 11 years. Oral localization developed before (n=2), at the same time as (n=2), or after (n=5) the onset of the digestive disease. Noticeable associated localizations were observed in the anoperineum (n=8) and the esophagus (n=3). The median duration of the oral lesions was 4 years (range, 1-13 years), without necessary parallelism with the digestive localization. Five patients had complete healing after a median delay of 2 years.
Conclusions Oral localization of Crohn disease is characterized by a marked male predominance, a young age at onset of Crohn disease, and a very protracted course. The high prevalence of associated anal and esophageal involvement suggests that Crohn lesions have a particular trophicity for squamous cell epithelium.
From the Departments of Dermatology (Drs Dupuy, Revuz, and Cosnes) and Hepatogastroenterology (Dr Delchier), Hôpital Henri Mondor, Creteil, and the Department of Hepatogastroenterology, Hôpital Rothschild, Paris (Drs Gendre and Cosnes), France.
RELATED ARTICLE
Archives of Dermatology Reader's Choice: Continuing Medical Education
Arch Dermatol. 1999;135(4):480-481.
FULL TEXT
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Granulomatous Cheilitis and Borrelia burgdorferi: Polymerase Chain Reaction and Serologic Studies in a Retrospective Case Series of 12 Patients
Muellegger et al.
Arch Dermatol 2000;136:1502-1506.
ABSTRACT
| FULL TEXT
|
