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Prospective, Single-blind, Randomized, Controlled Study to Assess the Efficacy of the 585-nm Flashlamp-Pumped Pulsed-Dye Laser and Silicone Gel Sheeting in Hypertrophic Scar Treatment
Gregory P. Wittenberg, MD;
Brian G. Fabian, MD;
Jodie L. Bogomilsky, MD;
Lonni R. Schultz, PhD;
Earl J. Rudner, MD;
Marsha L. Chaffins, MD;
Ghassan M. Saed, PhD;
Robert L. Burns, MD;
David P. Fivenson, MD
Arch Dermatol. 1999;135:1049-1055.
Objective To determine the efficacy of the 585-nm flashlamp-pumped pulsed-dye laser and silicone gel sheeting in the treatment of hypertrophic scars in lighter- and darker-skinned patients.
Design Prospective, single-blind, randomized, internally controlled, comparison investigation.
Setting Large academic dermatology department.
Patients Twenty patients with hypertrophic scars (19 completed the laser treatments and 18 completed the silicone gel sheeting treatments).
Main Outcome Measures Clinical measurements included hypertrophic scar blood flow, elasticity, and volume. Patients' subjective complaints of pruritus, pain, and burning were also monitored. Histological assessment of fibrosis, number of telangiectasias, and number of mast cells was performed. Statistically significant improvements in clinical measurements and patients' subjective complaints determined treatment success.
Results Mean scar duration was 32 months (range, 4 months to 20 years). There was an overall reduction in blood flow, volume, and pruritus over time (P=.001, .02, and .005, respectively). However, no differences were detected among treatment and control groups. There was no reduction in pain or burning (0-40 weeks), elasticity (8-40 weeks), or fibrosis (0-40 weeks, n=5 biopsies) in the treated or control sections of the scars. Unlike in a previous study, the number of mast cells in the scars was similar to the number of mast cells in healthy skin.
Conclusion Clinical results demonstrate that the improvements in scar sections treated with silicone gel sheeting and pulsed-dye laser were no different than in control sections.
From the Departments of Dermatology (Drs Wittenberg, Fabian, Bogomilsky, Rudner, Chaffins, Saed, Burns, and Fivenson) and Biostatistics (Dr Schultz), Henry Ford Health System, Detroit, Mich. Dr Wittenberg is now with Rapid City Medical Center, Rapid City, SD.
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