This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (33)  • Contact me when this article is cited  Related Content  • Related article  • Similar articles in this journal  Topic Collections  • Dermatologic Disorders  • Neoplasms  • Prognosis/ Outcomes  • Alert me on articles by topic  Social Bookmarking   What's this?

Kari Hemminki, MD, PhD; Chuanhui Dong, MD, PhD

Arch Dermatol. 2000;136:647-651.

Objectives  To compare cancer risks after in situ and invasive squamous cell carcinoma (SCC) of the skin and to determine whether these 2 forms of cancer differ in prognostic significance.

Patients  Subsequent events after in situ and invasive SCC were studied in the Swedish Family-Cancer Database, in which cancer data were obtained from the Swedish Cancer Registry from 1958 to 1996. Among 22,293 patients with in situ SCC, 3940 had first invasive cancer; among 17,637 patients with invasive SCC, 3624 had a second occurrence of cancer.

Main Outcome Measure  Standardized incidence ratios (SIRs), ratios of the observed to expected number of cases, served as a measure of relative risk. For overall risks, cases diagnosed within the first year of follow-up were omitted.

Results  The median age of onset was 72 to 73 years for in situ and invasive SCC, respectively. Standardized incidence ratios of all cancers were increased after in situ SCC (men-women, 1.5:1.3) and invasive SCC (men-women, 1.9:1.5). The subsequent occurrences of cancer and their SIRs were similar after in situ and invasive SCC, with skin cancer showing the highest SIR of 6.4:10.0. Among discordant cancers, increased SIRs were recorded for melanoma and a group of malignant neoplasms observed in patients with immunosuppression, including lymphoma and oral cancers. Subsequent cancers in the salivary glands and nasal cavity also showed increased SIRs, particularly after invasive SCC.

Conclusion  Risks of subsequent cancers, including skin cancer, melanoma, and internal cancers, showed similar patterns in patients with in situ and invasive SCC, suggesting that the 2 groups have a similar susceptibility to cancer.

From the Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

RELATED ARTICLE

Archives of Dermatology Reader's Choice: Continuing Medical Education
Arch Dermatol. 2000;136(5):683.
FULL TEXT  

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Nonmelanoma Skin Cancer and Risk for Subsequent Malignancy
Chen et al.
JNCI J Natl Cancer Inst 2008;100:1215-1222.
ABSTRACT | FULL TEXT  

Are Patients with Skin Cancer at Lower Risk of Developing Colorectal or Breast Cancer?
Soerjomataram et al.
Am J Epidemiol 2008;167:1421-1429.
ABSTRACT | FULL TEXT  

Skin Squamous Cell Cancer: The Time Is Right for Greater Involvement of the Medical Oncologist
Pfister and Halpern
JCO 2007;25:1953-1954.
FULL TEXT  

XPD Polymorphism and Risk of Subsequent Cancer in Individuals with Nonmelanoma Skin Cancer
Brewster et al.
Cancer Epidemiol. Biomarkers Prev. 2004;13:1271-1275.
ABSTRACT | FULL TEXT  

Time Trends and Familial Risks in Squamous Cell Carcinoma of the Skin
Hemminki et al.
Arch Dermatol 2003;139:885-889.
ABSTRACT | FULL TEXT