 |
|
Subsequent Cancers After In Situ and Invasive Squamous Cell Carcinoma of the Skin
Kari Hemminki, MD, PhD;
Chuanhui Dong, MD, PhD
Arch Dermatol. 2000;136:647-651.
Objectives To compare cancer risks after in situ and invasive squamous cell carcinoma (SCC) of the skin and to determine whether these 2 forms of cancer differ in prognostic significance.
Patients Subsequent events after in situ and invasive SCC were studied in the Swedish Family-Cancer Database, in which cancer data were obtained from the Swedish Cancer Registry from 1958 to 1996. Among 22,293 patients with in situ SCC, 3940 had first invasive cancer; among 17,637 patients with invasive SCC, 3624 had a second occurrence of cancer.
Main Outcome Measure Standardized incidence ratios (SIRs), ratios of the observed to expected number of cases, served as a measure of relative risk. For overall risks, cases diagnosed within the first year of follow-up were omitted.
Results The median age of onset was 72 to 73 years for in situ and invasive SCC, respectively. Standardized incidence ratios of all cancers were increased after in situ SCC (men-women, 1.5:1.3) and invasive SCC (men-women, 1.9:1.5). The subsequent occurrences of cancer and their SIRs were similar after in situ and invasive SCC, with skin cancer showing the highest SIR of 6.4:10.0. Among discordant cancers, increased SIRs were recorded for melanoma and a group of malignant neoplasms observed in patients with immunosuppression, including lymphoma and oral cancers. Subsequent cancers in the salivary glands and nasal cavity also showed increased SIRs, particularly after invasive SCC.
Conclusion Risks of subsequent cancers, including skin cancer, melanoma, and internal cancers, showed similar patterns in patients with in situ and invasive SCC, suggesting that the 2 groups have a similar susceptibility to cancer.
From the Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden.
RELATED ARTICLE
Archives of Dermatology Reader's Choice: Continuing Medical Education
Arch Dermatol. 2000;136(5):683.
FULL TEXT
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Nonmelanoma Skin Cancer and Risk for Subsequent Malignancy
Chen et al.
JNCI J Natl Cancer Inst 2008;100:1215-1222.
ABSTRACT
| FULL TEXT
Are Patients with Skin Cancer at Lower Risk of Developing Colorectal or Breast Cancer?
Soerjomataram et al.
Am J Epidemiol 2008;167:1421-1429.
ABSTRACT
| FULL TEXT
Skin Squamous Cell Cancer: The Time Is Right for Greater Involvement of the Medical Oncologist
Pfister and Halpern
JCO 2007;25:1953-1954.
FULL TEXT
XPD Polymorphism and Risk of Subsequent Cancer in Individuals with Nonmelanoma Skin Cancer
Brewster et al.
Cancer Epidemiol. Biomarkers Prev. 2004;13:1271-1275.
ABSTRACT
| FULL TEXT
Time Trends and Familial Risks in Squamous Cell Carcinoma of the Skin
Hemminki et al.
Arch Dermatol 2003;139:885-889.
ABSTRACT
| FULL TEXT
|
