 |
|
Clinicopathologic, Immunophenotypic, and Molecular Characterization of Primary Cutaneous Follicular B-Cell Lymphoma
Reuven Bergman, MD;
Paul J. Kurtin, MD;
Lawrence E. Gibson, MD;
Peter R. Hull, MD, PhD, FRCPC, FFDerm(SA);
Teresa K. Kimlinger, BA;
Arnold L. Schroeter, MD
Arch Dermatol. 2001;137:432-439.
Objective To determine the clinicopathologic, immunophenotypic, and molecular characteristics of primary follicular cutaneous B-cell lymphoma (CBCL) as defined by the revised European-American lymphoma classification.
Design A retrospective survey of the medical records, an immunohistochemical study of archival biopsy specimens. and molecular studies of preserved DNA of all patients with follicle center lymphoma-follicular (FCL-F) primary CBCL from 1987 to 1997.
Setting A single-center outpatient specialty clinic at an academic medical center.
Patients Twenty-one patients (68% of all new primary CBCL cases), including 14 men and 7 women (age range, 33-88 years; mean, 55 years).
Results The head and neck region was the most frequent primary site. Following treatment, recurrences were relatively frequent, but the overall mortality rate during 1.0 to 11.3 years (mean, 6.3 years) of follow-up was 4.8%. Immunohistochemical analysis for B- and T-cell lineages was helpful in enhancing the folliclelike structures. CD10, bcl-2, and CD43 were expressed by the neoplastic cells in 9 (47%) of 19 cases, 4 (21%) of 19 cases, and 2 (13%) of 16 cases, respectively. Immunohistochemical detection of cytoplasmic immunoglobulin light chains, using steaming in EDTA as the antigen-retrieval technique, was successful in 12 (71%) of 17 cases. The Ig heavy-chain gene rearrangements, using the Southern blot technique, detected clonality in 17 (94%) of 18 cases. The bcl-2 gene rearrangements were detected in only 2 (13%) of 15 of the primary cutaneous FCL-F cases, compared with 9 (75%) of 12 of the primary nodal FCL-F cases (P = .002).
Conclusions Primary cutaneous FCL-F is a relatively common subtype of CBCL, with a relatively indolent course. It has many features in common with primary nodal FCL-F, except for low rates of bcl-2 expression and bcl-2 gene rearrangements.
RELATED ARTICLES
Primary Cutaneous Follicular Lymphoma
Lorenzo Cerroni and Helmut Kerl
Arch Dermatol. 2001;137(4):489-490.
EXTRACT
| FULL TEXT
Archives of Dermatology Reader's Choice: Continuing Medical Education
Arch Dermatol. 2001;137(4):520.
FULL TEXT
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
European Organization for Research and Treatment of Cancer and International Society for Cutaneous Lymphoma consensus recommendations for the management of cutaneous B-cell lymphomas
Senff et al.
Blood 2008;112:1600-1609.
ABSTRACT
| FULL TEXT
WHO-EORTC classification for cutaneous lymphomas
Willemze et al.
Blood 2005;105:3768-3785.
ABSTRACT
| FULL TEXT
Molecular Diagnosis of Cutaneous Diseases
Sra et al.
Arch Dermatol 2005;141:225-241.
ABSTRACT
| FULL TEXT
Effect of Fixatives and Tissue Processing on the Content and Integrity of Nucleic Acids
Srinivasan et al.
Am. J. Pathol. 2002;161:1961-1971.
ABSTRACT
| FULL TEXT
Primary Cutaneous Follicular Lymphoma: An Assessment of Clinical, Histopathologic, Immunophenotypic, and Molecular Features
Mirza et al.
JCO 2002;20:647-655.
ABSTRACT
| FULL TEXT
Lymphoma of the Skin
Connors et al.
ASH Education Book 2002;2002:263-282.
ABSTRACT
| FULL TEXT
Characterization of Cutaneous Follicular B-Cell Lymphomas
Journal Watch Dermatology 2001;2001:2-2.
FULL TEXT
|
