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Discordance Between Facial Wrinkling and the Presence of Basal Cell Carcinoma
Rebecca C. C. Brooke, MRCP;
Sophie A. Newbold, MB, ChB;
Nicholas R. Telfer, FRCP;
Christopher E. M. Griffiths, MD, FRCP
Arch Dermatol. 2001;137:751-754.
Background During routine surgical treatment of basal cell carcinomas (BCCs), we observed an apparent inverse relationship between the presence of a BCC and significant wrinkling of the face. To ascertain the veracity of this observation, we performed a clinical and questionnaire-based case-referent study.
Observation One hundred eighteen successive white patients (mean ± SD age, 71.9 ± 9.5 years) attending the hospital for surgical treatment of a BCC and 121 control (no skin cancer) patients (mean ± SD age, 69.1 ± 10.8 years) were assessed for grade of facial wrinkling using a previously validated photonumeric scale of photoaging and completed a questionnaire about sun exposure. Despite being older (P = .03), patients with a BCC were found to have a lower mean grade of wrinkling than controls (P = .001). Using logistic regression, increasing grade of wrinkling was associated with a progressive reduction in risk of developing a BCC.
Conclusion Mechanisms responsible for the production of facial wrinkles may either be separate to or mitigate against the development of a BCC of the face.
From the Dermatology Centre, Hope Hospital, The University of Manchester, Manchester, England.
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