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Agminated Atypical (Dysplastic) Nevi
Case Report and Review of the Literature
Ashfaq A. Marghoob, MD;
Robin Blum, BS;
Robert Nossa, MD;
Klaus J. Busam, MD;
Dana Sachs, MD;
Allan Halpern, MD
Arch Dermatol. 2001;137:917-920.
Background Patients with the atypical mole syndrome have multiple dysplastic nevi that appear to be randomly distributed on certain preferred anatomical sites such as the upper back. These dysplastic nevi are thought to be acquired melanocytic nevi that begin appearing at puberty. To our knowledge, the presence of agminated atypical (dysplastic) nevi has not been reported.
Observation We describe a patient with the atypical mole syndrome who has more than 100 melanocytic nevi, many of which are clinically atypical and one of which proved to be a melanoma. Among his many melanocytic nevi is a cluster of approximately 50 nevi that are distributed in an area measuring 5 x 3 cm. The histopathologic features of these nevi are consistent with the diagnosis of "dysplastic nevus."
Conclusions To our knowledge, agminated atypical (dysplastic) nevi have not been described previously. The presence of agminated atypical (dysplastic) nevi in a patient with the atypical mole syndrome can be theorized to arise because of loss of heterozygosity.
From the Dermatology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY (Drs Marghoob, Busam, Sachs, and Halpern); and the Departments of Dermatology, State University of New York at Stony Brook (Dr Marghoob) and Mount Sinai Medical Center, New York (Ms Blum and Dr Nossa).
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