Subacute Cutaneous Lupus Erythematosus Induced or Exacerbated by Terbinafine
A Report of 5 Cases
Jeffrey P. Callen, MD;
Amy P. Hughes, MD;
Carol Kulp-Shorten, MD
Arch Dermatol. 2001;137:1196-1198.
Background Subacute cutaneous lupus erythematosus is a nonscarring, non–atrophy-producing photosensitive cutaneous disorder. Half of the patients have 4 or more of the criteria for classification as systemic lupus erythematosus. In some patients, drugs induce or exacerbate the cutaneous disease.
Observation We describe 5 patients who had either an exacerbation or a new onset of subacute cutaneous lupus erythematosus while taking terbinafine for presumed onychomycosis.
Conclusion In general, terbinafine is a safe drug, but perhaps patients with known lupus erythematosus or photosensitivity are predisposed to drug-induced or drug-exacerbated disease.
From the Division of Dermatology, Department of Medicine, University of Louisville School of Medicine, Louisville, Ky.
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