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Viral Disease Transmitted by Laser-Generated Plume (Aerosol)
Jerome M. Garden, MD;
M. Kerry O'Banion, MD, PhD;
Abnoeal D. Bakus, PhD;
Carl Olson, DVM, PhD
Arch Dermatol. 2002;138:1303-1307.
Objective To evaluate the possibility of disease transmission through liberated
plume from virally infected tissue that is exposed to the carbon dioxide laser.
Design Bovine papillomavirus–induced cutaneous fibropapillomas were exposed
to the carbon dioxide laser. Laser settings were within the range of clinically
used settings. The laser plume (aerosol) was suctioned and collected and then
reinoculated onto the skin of calves.
Setting University laboratory research center.
Main Outcome Measures Laser plume viral content and postinoculation tumor growth were analyzed
and documented.
Results Collected laser plume contained papillomavirus DNA in all tested laser
settings. The viral DNA was most likely encapsulated. Tumors developed at
laser plume–inoculated sites for all laser parameter settings. Histological
and biochemical analyses revealed that these tumors were infected with the
same virus type as present in the laser plume.
Conclusions Laser plume has been shown, for the first time to our knowledge, to
actually transmit disease. Strict care must be maintained by the laser practitioner
to minimize potential health risks, especially when treating viral-induced
lesions or patients with viral disease.
From the Departments of Dermatology (Drs Garden and Bakus) and Biomedical
Engineering (Dr Garden), Northwestern University, the Divisions of Dermatology
and Plastic Surgery, The Children's Memorial Hospital, (Dr Garden) Chicago,
Ill; the Department of Medicine, University of Rochester, Rochester, NY (Dr
O'Banion); and the Department of Veterinary Science, University of Wisconsin,
Madison (Dr Olson).
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