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Extrafacial and Generalized Granulomatous Periorificial Dermatitis
Amy J. Urbatsch, MD;
Ilona Frieden, MD;
Mary L. Williams, MD;
Boni E. Elewski, MD;
Anthony J. Mancini, MD;
Amy S. Paller, MD
Arch Dermatol. 2002;138:1354-1358.
Background Granulomatous periorificial dermatitis is a well-recognized entity presenting
most commonly in prepubertal children as yellow-brown papules limited to the
perioral, perinasal, and periocular regions. The condition is self-limiting
and is not associated with systemic involvement.
Observations We reviewed the medical charts of 5 healthy children presenting with
extrafacial granulomatous papules in addition to the typical periorificial
papules. These extrafacial lesions were clinically and histologically identical
to the facial lesions, were self-limiting, and were not associated with systemic
involvement. Resolution seemed to be hastened with the use of systemic antibiotic
therapy in 4 of the 5 patients.
Conclusions Extrafacial lesions can occur in granulomatous periorificial dermatitis
and do not appear to adversely affect the duration, response to therapy, or
risk of extracutaneous manifestations. Overly aggressive evaluation and inappropriate
systemic therapy should be avoided.
From the Department of Dermatology, University of Alabama at Birmingham
(Drs Urbatsch and Elewski); Department of Pediatric Dermatology, University
of California at San Francisco (Drs Frieden and Williams); and Department
of Pediatric Dermatology, Northwestern University Medical School, Chicago,
Ill (Drs Mancini and Paller).
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