
Junctional CD8+ Cutaneous Lymphomas With Nonaggressive Clinical Behavior
A CD8+ Variant of Mycosis Fungoides?
Reinhard Dummer, MD;
Jivko Kamarashev, MD;
Werner Kempf, MD;
Andreas C. Häffner, MD;
Monika Hess-Schmid, MD;
Günter Burg, MD
Arch Dermatol. 2002;138:199-203.
Objective To evaluate the clinical and prognostic features in primary cutaneous
CD8+ T-cell lymphomas, which are rare and considered to be aggressive
cutaneous lymphoproliferative disorders.
Design Single-center retrospective study.
Setting Lymphoma clinic (referral center) of a university hospital.
Patients Three patients presented with CD8+ cutaneous lymphoma characterized
by a patchlike pattern and hyperpigmentation.
Results Histological analysis revealed a CD3+, CD8+ small-cell
infiltrate showing a remarkable affinity to the dermoepidermal junction zone.
Clonality for the T-cell receptor chain was detected by polymerase
chain reaction followed by denaturing gradient gel electrophoresis. The clinical
presentation lasted several years (6 and 9 years, respectively) before the
correct diagnosis was made. Treatment with nontoxic approaches (UV-B and local
steroids) was successful. Aggressive clinical behavior was not observed.
Conclusions Our 3 cases of junctional CD8+ cutaneous T-cell lymphomas
were characterized by hyperpigmentation and nonaggressive clinical behavior.
This type of lymphoma, which can be considered a CD8+ mycosis fungoides
variant, must be distinguished from other types of cutaneous CD8+
lymphomas so that overtreatment can be avoided.
From the Department of Dermatology, University of Zurich Medical School,
Zurich, Switzerland.
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