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Frequency and Severity of Systemic Disease in Patients With Subacute Cutaneous Lupus Erythematosus
Dana R. Black, MD;
Carlton A. Hornung, PhD, MPH;
Paul D. Schneider, MD;
Jeffrey P. Callen, MD
Arch Dermatol. 2002;138:1175-1178.
Objective To compare the frequency and severity of systemic disease in patients
with subacute cutaneous lupus erythematosus (SCLE) followed up in a dermatology
practice vs patients with systemic lupus erythematosus (SLE) followed up in
a rheumatology practice.
Design Case-control comparison of patients matched for age, sex, and ethnicity.
Setting University-affiliated dermatology and rheumatology practices.
Patients Seventy-six patients with SCLE were compared with 24 patients with SLE.
Intervention All medical records were reviewed and the patients were interviewed.
Main Outcome Measures Systemic and serologic findings were compared between patients with
SCLE and those with SLE.
Results Hematologic disorders were present in 6 patients (8%) with SCLE and
in 13 patients (54%) with SLE (P<.001). Serositis
was present in 1 patient (1%) with SCLE and in 3 patients (12%) with SLE (P = .04). Renal involvement was present in 12 patients
(16%) with SCLE and in 6 patients (25%) with SLE (P
= .36). Antinuclear antibodies were found in 52 patients (68%) with SCLE compared
with 23 patients (96%) with SLE (P = .006). Anti-Ro
antibodies were found in 37 patients (49%) with SCLE compared with 10 patients
(42%) with SLE (P = .64). Other serologic abnormalities
(anti–native DNA, anti-Sm antibody, or anti-U1RNP) were present
in 6 patients (8%) with SCLE compared with 15 patients (62%) with SLE (P<.001). Photosensitivity was present in 65 patients
(86%) with SCLE, compared with 11 patients (46%) with SLE (P<.001).
Conclusions This analysis reveals a dissimilar frequency of internal organ involvement
between patients with SCLE and SLE. Renal disease was similar in frequency
and severity, and documented central nervous system involvement was rare in
both groups.
From the Divisions of Dermatology (Drs Black and Callen), General Medicine
(Dr Hornung), and Rheumatology (Dr Schneider), Department of Medicine, University
of Louisville School of Medicine, Louisville, Ky.
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Arch Dermatol 2003;139:89-90.
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