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Markus Böhm, MD; Uta Frieling, MD; Thomas A. Luger, MD; Gisela Bonsmann, MD

Arch Dermatol. 2003;139:922-924.

Background  Lichen sclerosus of the anogenital area is a chronic inflammatory and fibrosclerotic disease associated with substantial morbidity. Topical ultrapotent corticosteroids are currently the treatment of choice.

Observations  Three prepubertal girls and 3 adults (2 men, 1 woman) were treated with 0.1% tacrolimus ointment once daily. All patients experienced complete resolution with long-lasting remission for up to 1 year. No major adverse effects were observed, and treatment was well tolerated.

Conclusions  Topical tacrolimus is a promising novel agent in the treatment of lichen sclerosus of the anogenital area. A major advantage over topical corticosteroids is the lack of skin atrophy. Further clinical trials are warranted to confirm our findings.

From the Department of Dermatology, University of Münster, Münster, Germany. The authors have no relevant financial interest in this article.

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