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Eruptive Xanthomas Associated With Olanzapine Use
Howard Y. Chang, MD, PhD;
Todd W. Ridky, MD, PhD;
Alexandra B. Kimball, MD, MPH;
Elizabeth Hughes, MD;
Anthony E. Oro, MD, PhD
Arch Dermatol. 2003;139:1045-1048.
Background Since their introduction to the US market, atypical antipsychotic drugs, such as olanzapine, have been widely prescribed for the management of psychosis and have increasingly been used in dermatologic settings for the treatment of psychogenic dermatoses. Mild hyperglycemia and hypertriglyceridemia have been documented from the use of these medications, but the range of effects on metabolism and the effects on skin are poorly characterized.
Observation We describe 3 patients who developed eruptive xanthomas, 1 of whom had relative insulin insufficiency, after starting olanzapine therapy. These cases further support the association of severe dyslipidemia with olanzapine use in selected patients.
Conclusion With the increasing use of atypical antipsychotic agents in the dermatologic setting, the dyslipidemia that develops in association with olanzapine use emphasizes the need for periodic metabolic studies in high-risk patients.
From the Department of Dermatology, Program in Epithelial Biology, Stanford University School of Medicine, Stanford, Calif. The authors have no relevant financial interest in this article.
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