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Jacob Mashiah, MD; Sarah Brenner, MD

Arch Dermatol. 2003;139:1181-1183.

Background  Patch tests are considered safe but adverse reactions have been reported.

Observations  A case of acute generalized exanthematous pustulosis (AGEP) provoked by a patch test with acetaminophen is described. Of special interest are the negative patch test results obtained with the offending drug. The case is discussed against the background of the putative mechanisms of AGEP and the reported systemic reactions to patch testing for AGEP.

Conclusions  To our knowledge, this is the first report in the English-language literature of a generalized AGEP-like reaction caused by patch tests carried out to determine the drug eliciting AGEP.

From the Department of Dermatology, Tel Aviv Sourasky Medical Center, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. The authors have no relevant financial interest in this article.

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