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A Study of 6 Hemizygous Men and 5 Heterozygous Women With Emphasis on Dermatologic Manifestations

Margarita Larralde, MD, PhD; Paula Boggio, MD; Hernán Amartino, MD; Néstor Chamoles, MD

Arch Dermatol. 2004;140:1440-1446.

Objective  To determine the significance of the dermatologic and systemic abnormalities found in 11 patients with Fabry disease (FD) which is an X-linked lysosomal storage disorder caused by the partial or complete deficiency of the -galactosidase A enzyme. This defect leads to the accumulation of uncleaved glycosphingolipids throughout vascular endothelium and visceral tissues.

Design  Case series.

Setting  Pediatric Dermatology Division, Ramos Mejía Hospital (primary care center) and Laboratory of Neurochemistry (referral center for metabolic diseases).

Patients  Eleven patients with FD were studied: 6 hemizygous men (mean age, 23.0 years) and 5 heterozygous women (mean age, 49.4 years).

Results  Mucocutaneous angiokeratomas (AKs) were found in 5 (83%) of 6 hemizygotes and 4 (80%) of 5 heterozygotes. The AKs appeared at an average age of 13 years, affecting predominantly genitalia, back, elbows, and other frequently traumatized areas. All the hemizygotes and none of the heterozygotes suffered from hypohidrosis. Angiokeratomas on the trunk and oral mucosa without sweat abnormalities were detected in 80% of heterozygous women. All hemizygotic men presented with acral pain in childhood.

Conclusion  We emphasize the value of early recognition of AKs and hypohidrosis as diagnostic clues to FD, a severe and progressive disorder.

Author Affiliations: Pediatric Dermatology Department, Ramos Mejía Hospital (Drs Larralde and Boggio), and Laboratory of Neurochemistry (Drs Amartino and Chamoles), Buenos Aires, Argentina.

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Fabry Disease: More Than Angiokeratomas
Matthias Möhrenschlager, Verena Henkel, and Johannnes Ring
Arch Dermatol. 2004;140(12):1526-1528.
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Fabry Disease: More Than Angiokeratomas
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Arch Dermatol 2004;140:1526-1528.
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