 |
|
An Optimal Method for Experimental Provocation of Polymorphic Light Eruption
Chantalle B. van de Pas, MD;
John L. Hawk, MD, FRCP;
Antony R. Young, PhD;
Susan L. Walker, PhD
Arch Dermatol. 2004;140:286-292.
Background There is controversy about the best method to induce polymorphic light eruption (PLE) experimentally.
Objectives To review articles on PLE induction and design a UV radiation protocol that improves success rates with clinically relevant doses of environmentally relevant solar-simulated radiation (SSR).
Design and Setting All articles on the experimental provocation of PLE published since 1980 were reviewed. Photoprovocation of lesions was studied in 25 PLE patients. The 24-hour minimal erythemal dose (MED) of SSR was determined. Thereafter, six 4 x 4-cm adjacent sites on previously affected and previously unaffected skin were exposed to 0.25, 0.5, 0.75, 1.0, 1.25, 1.5 MED of SSR for 3 to 4 consecutive days. The study periodwas autumn to spring in London, England (51° north latitude).
Main Outcome Measures Relationship between PLE induction and biological and physical exposure parameters.
Conclusions The review shows that fractionated erythemally effective UV-A exposures were more successful than single-sunburning UV-B doses. Photoprovocation of PLE was successful in 68% of patients after 2 to 3 SSR exposures that were not necessarily erythemal. There was no difference in success rate between previously affected and previously unaffected skin. Our data indicate that PLE is more likely to be induced when the natural causes of the disease are simulated.
From the St John's Institute of Dermatology, Guy's, King's, and St Thomas' School of Medicine, King's College London, England. The authors have no relevant financial interest in this article.
RELATED ARTICLES
Differential Expression of Cytokines in UV-B–Exposed Skin of Patients With Polymorphous Light Eruption: Correlation With Langerhans Cell Migration and Immunosuppression
Wendy Kölgen, Marjan van Meurs, Marjan Jongsma, Huib van Weelden, Carla A. F. M. Bruijnzeel-Koomen, Edward F. Knol, Willem A. van Vloten, Jon Laman, and Frank R. de Gruijl
Arch Dermatol. 2004;140(3):295-302.
ABSTRACT
| FULL TEXT
Polymorphic Light Eruption Reassessed
Lesley E. Rhodes
Arch Dermatol. 2004;140(3):351-352.
EXTRACT
| FULL TEXT
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Susceptibility to UV-A and UV-B Provocation Does Not Correlate With Disease Severity of Polymorphic Light Eruption
Janssens et al.
Arch Dermatol 2007;143:599-604.
ABSTRACT
| FULL TEXT
Polymorphic Light Eruption Reassessed
Rhodes
Arch Dermatol 2004;140:351-352.
FULL TEXT
|
