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Cheryl Lee D. Eberting, MD; Joie Davis, APRN, APNG; Jennifer M. Puck, MD; Steven M. Holland, MD; Maria L. Turner, MD

Arch Dermatol. 2004;140:1119-1125.

Objective  To characterize the dermatitis, the newborn rash, and cutaneous findings in hyper-IgE syndrome, also known as Job's syndrome.

Design  Prospective and retrospective evaluation and treatment of cutaneous manifestations in patients with a clinical diagnosis of hyper-IgE syndrome (HIES). Analysis of the newborn rash encountered in this population.

Setting  Dermatology clinic at the National Institutes of Health, Bethesda, Md.

Patients  Forty-three patients seen in our clinic between January 1998 and August 2003 who had a clinical diagnosis of HIES.

Interventions  The UK Working Party's Diagnostic Criteria for Atopic Dermatitis were used to assess for atopic dermatitis in this population. To assess the newborn rash, we performed a retrospective chart review and an in-person or telephone interview of the parent or caregiver of each patient.

Results  Twenty-eight (65%) of 43 patients fulfilled the criteria for atopic dermatitis. Thirty-five (81%) of 43 patients reported a newborn rash. Eight (19%) of 43 were born with the rash; 23 (53%) of 43 had acquired the rash within 7 days; 32 (74%) of 43 within 14 days; 34 (79%) of 43 within 30 days; and 35 (81%) of 43 had the rash within 35 days of birth.

Conclusions  The dermatitis in HIES resembles classic atopic dermatitis but may have distinctive features. A newborn rash is almost always a presenting sign of HIES. After the newborn period, skin findings include retroauricular fissures, external otitis, infected dermatitis of the axillae and groin, folliculitis of the upper back and shoulders, cutaneous abscesses, mucocutaneous candidiasis, and in some patients pitted scarring of the face.

From the Dermatology Branch, Center for Cancer Research, National Cancer Institute (Drs Eberting and Turner), the National Human Genome Research Institute (Ms Davis and Dr Puck), and the National Institute of Allergy and Infectious Diseases (Dr Holland), Bethesda, Md. The authors have no relevant financial interest in this article.

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