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Marielle Burnouf, MD; Marc Buffet, MD; Michaël Schwarzinger, MD; Philippe Roman, MD; Patrick Bui, MD; Marianne Prévot, MD; Jean Deleuze, MD; Jean Pierre Morini, MD; Nathalie Franck, MD; Isabelle Gorin, MD; Nicolas Dupin, MD

Arch Dermatol. 2005;141:1220-1224.

Objective  To evaluate the efficiency of Coleman lipostructure in patients infected with human immunodeficiency virus (HIV).

Design  Open-label study and survey.

Setting  Ambulatory dermatosurgery department of a university hospital.

Patients  Thirty-three consecutive HIV-infected patients undergoing Coleman lipostructure between 2000 and 2001.

Interventions  Clinical examination, blood tests, and standardized photographs at baseline and 1 year after the lipostructure.

Mean Outcome Measures  Efficiency was assessed by the agreement of 3 independent medical specialists on facial lipodystrophy improvement after surgery and by patient satisfaction.

Results  Facial lipoatrophy was improved in 12 patients (36%; 95% confidence interval, 20%-52%) as judged by all 3 evaluators. Quantity of fat injected (P = .01) and a low serum triglyceride level before surgery (P = .03) were significantly associated with improvement of facial lipoatrophy. Of the 33 patients, 14 (43%) were very satisfied, 17 (50%) were partly satisfied, and 27 (81%) had a better quality of life. The most common comment was that the patient looked better and appeared less ill.

Conclusion  Our 1-year evaluation of Coleman lipostructure for correction of facial lipoatrophy in HIV-infected patients proved the efficiency of this treatment when measured conservatively by agreement on improvement by 3 independent specialists and demonstrated a patient satisfaction rate of 93%.

Author Affiliations: Service de Dermatologie, Hôpital Tarnier-Cochin, Paris, France (Drs Burnouf, Buffet, Roman, Bui, Prévot, Deleuze, Morini, Franck, Gorin, and Dupin); and Service de Pharmacologie Clinique, Hôpital Henri Mondor, Créteil, France (Dr Schwarzinger).

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