This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Related articles  • Similar articles in this journal  Topic Collections  • Hematology/ Hematologic Malignancies  • Leukemias/ Lymphomas  • Neoplasms  • Alert me on articles by topic

Nathalie Franck, MD; Agnes Carlotti, MD; Isabelle Gorin, MD; Marc Buffet, MD; Christine Mateus, MD; Nicolas Dupin, MD, PhD; for the French Study Group on Cutaneous Lymphomas

Arch Dermatol. 2005;141:353-356.

Background  Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma (CTCL). Patients with limited patch and/or plaque disease have a normal life expectancy. Neutrophilic dermatosis (ND) may be associated with various hematologic disorders. However, its association with CTCL is exceptional and has been reported only twice with leukemic forms of CTCL.

Observations  Three patients with MF developed ND resistant to conventional therapies and responsible for an impaired quality of life due to constitutional symptoms and painful cutaneous lesions. All patients underwent an aggressive treatment course despite their varying initial clinical stages of MF, and all experienced a fatal outcome less than 18 months after the onset of ND.

Conclusions  The association of MF with ND is exceptional and carries a poor prognosis, but the pathophysiologic nature of this association remains unclear. It may involve neutrophil chemoattractant cytokine production by tumor cells. A triggering role of interferon alfa is also possible.

Author Affiliations: Departments of Dermatology (Drs Franck, Gorin, Buffet, Mateus, and Dupin) and Pathology (Dr Carlotti), Hopital Tarnier-Cochin, Paris, France.
Group Information: A list of the members of the French Study Group on Cutaneous Lymphomas appears in a box above.

RELATED ARTICLES

Long-term Follow-up of Patients With Early-Stage Cutaneous T-Cell Lymphoma Who Achieved Complete Remission With Psoralen Plus UV-A Monotherapy
Christiane Querfeld, Steven T. Rosen, Timothy M. Kuzel, Katharine A. Kirby, Henry H. Roenigk, Jr, Bettina M. Prinz, and Joan Guitart
Arch Dermatol. 2005;141(3):305-311.
ABSTRACT | FULL TEXT  

Health-Related Quality-of-Life Assessment in Patients With Cutaneous T-Cell Lymphoma
Marie-France Demierre, Amy Tien, and Donald Miller
Arch Dermatol. 2005;141(3):325-330.
ABSTRACT | FULL TEXT  

Monoclonal T-Cell Dyscrasia of Undetermined Significance Associated With Recalcitrant Erythroderma
Robert Gniadecki and Ansgar Lukowsky
Arch Dermatol. 2005;141(3):361-367.
ABSTRACT | FULL TEXT  

Dyscrasias With "Undetermined Significance"
Günter Burg, Reinhard Dummer, and Werner Kempf
Arch Dermatol. 2005;141(3):382-384.
EXTRACT | FULL TEXT  

Drug-Induced Eosinophilia and Systemic Symptoms: Hypersensitivity or Peripheral T-Cell Lymphoma?
Nicolas Schleinitz, Véronique Veit, Diane Coso, Thérèse Aurran, Phillippe Berbis, and Jean-Robert Harle
Arch Dermatol. 2005;141(3):395-396.
EXTRACT | FULL TEXT  

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Newly Reported Associations with Neutrophilic Dermatoses
Journal Watch Dermatology 2005;2005:6-6.
FULL TEXT