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David J. DiCaudo, MD; Karel Jill Ortiz, MD; Stephanie J. Mengden, MD; Katherine K. Lim, MD

Arch Dermatol. 2005;141:881-884.

Background  Sweet syndrome (acute febrile neutrophilic dermatosis) may arise in association with a variety of underlying systemic diseases. Only 1 case of coccidioidomycosis-associated Sweet syndrome has previously been reported.

Observations  We describe 2 patients who developed Sweet syndrome during the onset of acute pulmonary coccidioidomycosis. Systemic antifungal therapy was given in both cases. Respiratory symptoms and skin lesions resolved within 5 weeks.

Conclusions  Sweet syndrome may be a presenting feature of coccidioidomycosis. Recognition of the underlying pulmonary infection is important so that inappropriate treatment with systemic corticosteroids can be avoided.

Author Affiliations: Department of Dermatology, Mayo Clinic, Scottsdale, Ariz.

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