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Which Variables Are Most Important to Patients?

Carolyn R. Charman, BM, BCh, MRCP; Andrea J. Venn, PhD; Hywel Williams, MSc, PhD, FRCP; Michael Bigby, MD

Arch Dermatol. 2005;141:1146-1151.

Background  There is wide variation in the objective visual variables used to measure atopic eczema severity in clinical trials, making comparison and interpretation of results difficult.

Objective  To provide a rationale for simplifying and standardizing objective atopic eczema scoring by investigating which visual variables provide the best measure of disease severity from the patient’s perspective.

Setting  The dermatology outpatient department at the Queen’s Medical Centre, University Hospital in Nottingham, and 5 local general practices.

Patients  One hundred eighty individuals with atopic eczema.

Interventions  Clinical examination with scoring of 7 clinical signs and disease extent, followed by regression analyses of visual variable scores against a patient-rated measure of current disease severity.

Results  Objective measurements account for only a quarter of the variation in patient-rated disease severity. Three clinical signs were independent predictors of patient-rated disease severity: excoriations, erythema, and edema/papulation. Disease extent measurements do not reflect patient-rated disease severity in a linear manner, with mean severity scores increasing little above 30% body surface area involvement.

Conclusions  From the patient’s perspective, the measurement of 3 clinical signs—excoriations, erythema, and edema/papulation—provides as much information about current atopic eczema severity as more complex scoring systems that measure multiple clinical signs and disease extent. The simplicity of the Three Item Severity score, a previously published atopic eczema score based on measurement of these 3 clinical signs, makes it a suitable tool for research studies or clinical practice.

Author Affiliations: Department of Dermatology, Queen’s Medical Centre (Drs Charman and Williams); and Department of Epidemiology and Public Health, University of Nottingham (Dr Venn); Nottingham, England.

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