 |
 |

Dermatologic Adverse Effects of Lenalidomide Therapy for Amyloidosis and Multiple Myeloma
Hans P. Sviggum, BA;
Mark D. P. Davis, MD;
S. Vincent Rajkumar, MD;
Angela Dispenzieri, MD
Arch Dermatol. 2006;142:1298-1302.
Objectives To examine dermatologic adverse effects of lenalidomide in patients with amyloidosis and multiple myeloma and to determine whether the adverse effects are different when lenalidomide is used alone compared with when it is used in combination with dexamethasone.
Design Retrospective review of medical records.
Setting Tertiary referral center.
Patients Seventy-five patients with multiple myeloma and 23 patients with amyloidosis participating in clinical trials.
Intervention In the 75 patients with multiple myeloma, lenalidomide was the treatment in 24 and lenalidomide and dexamethasone in 51. In the 23 patients with amyloidosis, lenalidomide was used alone.
Main Outcome Measures The frequency, type, severity, and time of onset of all skin eruptions that were temporally related to lenalidomide treatment were recorded.
Results In the patients with amyloidosis treated with lenalidomide, 10 (43%) had rashes. In the patients with multiple myeloma, rashes occurred in 7 (29%) of those receiving lenalidomide alone and in 15 (29%) of those receiving lenalidomide and dexamethasone. The rashes were characterized as morbilliform, urticarial, dermatitic, acneiform, and undefined. Severe rashes required permanent discontinuation of lenalidomide therapy in 2 patients. In 23 patients (72%), rashes occurred in the first month after therapy was initiated; however, delayed-onset rashes occurred in 9 (28%).
Conclusions The prevalence of dermatologic adverse effects in patients receiving lenalidomide was higher in those with amyloidosis than in those with multiple myeloma. The prevalence of skin eruptions was not diminished by the concurrent use of systemic corticosteroids. Most skin eruptions were mild and did not necessitate withdrawal of lenalidomide therapy.
Author Affiliations: Mayo Medical School, Mayo Clinic College of Medicine (Mr Sviggum), and Department of Dermatology (Dr Davis) and Division of Hematology (Drs Rajkumar and Dispenzieri), Mayo Clinic, Rochester, Minn.
CiteULike Connotea Del.icio.us Digg Reddit Technorati Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Erythema Multiforme/Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis in Lenalidomide-Treated Patients
Castaneda et al.
JCO 2009;27:156-157.
FULL TEXT
The activity of lenalidomide with or without dexamethasone in patients with primary systemic amyloidosis
Dispenzieri et al.
Blood 2007;109:465-470.
ABSTRACT
| FULL TEXT
|