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Effect of Topical Vitamin D Analogue on In Vivo Contact Sensitization
Kaija K. Hanneman, DO;
Heather M. Scull, MS;
Kevin D. Cooper, MD;
Elma D. Baron, MD
Arch Dermatol. 2006;142:1332-1334.
Background The immunomodulatory role of vitamin D and its analogues has been demonstrated in vitro and in vivo using animal models. We evaluated the effect of a vitamin D analogue, calcipotriene, in vivo on human subjects using a contact hypersensitivity model.
Observations Subjects were pretreated with topical calcipotriene, simulated solar radiation, or both on buttock skin. They were then sensitized and challenged using the contact allergen dinitrochlorobenzene. Immune response was measured by change in skinfold thickness before vs after elicitation across the challenge sites.
Conclusions Calcipotriene-treated individuals demonstrated 64% immunosuppression compared with untreated controls. This is equivalent to the immunosuppression induced by UV exposure.
Author Affiliations: Department of Dermatology, Skin Study Center, University Hospitals of Cleveland/Case Western Reserve University (Drs Hanneman, Cooper, and Baron and Ms Scull), and Department of Dermatology, Louis Stokes Veterans Affairs Medical Center (Drs Cooper and Baron), Cleveland, Ohio.
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Topically Applied 1,25-Dihydroxyvitamin D3 Enhances the Suppressive Activity of CD4+CD25+ Cells in the Draining Lymph Nodes
Gorman et al.
J. Immunol. 2007;179:6273-6283.
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