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A Risk Factor for Melanoma

Tamy B. H. Buckel, MD, MPH; Alisa M. Goldstein, PhD; Mary C. Fraser, RN, MA; Barbara Rogers, BA; Margaret A. Tucker, MD

Arch Dermatol. 2006;142:485-488.

Background  Individuals at increased risk of melanoma should use sun-protective measures to decrease their risk of developing melanoma.

Observation  We report a case of a 39-year-old patient with a CDKN2A mutation who developed 3 primary melanomas within a few years of initiating tanning bed use.

Conclusion  Intense UV exposure as an adult likely contributed to the development of additional primary melanomas in this individual.

Author Affiliations: Division of Cancer Prevention (Dr Buckel) and Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics (Drs Buckel, Goldstein, and Tucker and Mss Fraser and Rogers), National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Md. Dr Buckel is now with the Department of Dermatology, Penn State, Milton S. Hershey Medical Center, Hershey, Pa.