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Clinical and Histopathologic Features of 3 Cases and Review of the Literature

David J. DiCaudo, MD; James A. Yiannias, MD; Susan D. Laman, MD; Karen E. Warschaw, MD

Arch Dermatol. 2006;142:744-746.

Background  Coccidioidomycosis may be associated with a reactive generalized cutaneous eruption early in the course of the illness. Detailed descriptions in the literature are scarce.

Observations  We describe 3 patients with a florid eruption associated with pulmonary coccidioidomycosis. The exanthem mimicked erythema multiforme clinically but not histologically. In 2 of the patients, the eruption began before the presence of detectable antibodies in the serum.

Conclusion  The presence of the exanthem, in combination with fever and/or pneumonia, was a helpful clue to the diagnosis of coccidioidomycosis.

Author Affiliations: Department of Dermatology, Mayo Clinic Scottsdale, Scottsdale, Ariz.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

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