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Growth Inhibition of Trichophyton Species by Pseudomonas aeruginosa
James Treat, MD;
William D. James, MD;
Irving Nachamkin, DrPH, MPH;
John T. Seykora, MD, PhD
Arch Dermatol. 2007;143(1):61-64.
Objective To assess the ability of Pseudomonas aeruginosa to inhibit the growth of Trichophyton mentagrophytes (TM) and Trichophyton rubrum (TR).
Design Pseudomonas aeruginosa, Escherichia coli, or Staphylococcus epidermidis were grown in co-culture with either TM or TR.
Setting An academic medical center.
Main Outcome Measures The total fungal units and hyphal-spore ratio were measured at days 1, 5, 10, and 15.
Results There was a 73% and 46% reduction of total fungal units and a final hyphal-spore ratio of 0.16 and 0.04, respectively, when TM and TR were co-cultured with P aeruginosa. The number of fungal units increased when TM and TR were cultured with E coli (28% and 42%, respectively), S epidermidis (13% and 18%, respectively), and control media (44% and 62%, respectively), and the hyphal-spore ratio increased to above 30 in the presence of S epidermidis, E coli, and control media.
Conclusion Pseudomonas aeruginosa exhibits growth inhibitory properties against TM and TR.
Author Affiliations: Departments of Dermatology (Drs Treat, James, and Seykora) and Pathology and Laboratory Medicine (Dr Nachamkin), University of Pennsylvania School of Medicine, Philadelphia.
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