This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Topic Collections  • Dermatologic Disorders  • Wound Healing  • Dermatologic Disorders, Other  • Alert me on articles by topic  Social Bookmarking   What's this?

Marco Romanelli, MD, PhD; Valentina Dini, MD; Paolo Romanelli, MD

Arch Dermatol. 2007;143(10):1310-1313.

Background  The development of painful leg ulcers in the ankle area is a rare and only partially described complication in patients receiving high-dose, long-term hydroxyurea treatment for myeloproliferative diseases. Several reports have described treatments for chronic wound management with this type of lesion.

Observations  We describe 2 patients who were diagnosed as having hydroxyurea-induced leg ulcers that were successfully treated with a freeze-dried sponge containing oxidized regenerated cellulose and bovine purified collagen. This dressing is able to modulate the activity of proteases such as plasmin, neutrophil-derived elastase, and matrix metalloproteinase by physically entrapping them and thus inhibiting their activity.

Conclusion  This case demonstrates that topical application of a matrix metalloproteinase modulator can be a successful and safe treatment option for patients with hydroxyurea-induced recalcitrant leg ulcers.

Author Affiliations: Department of Dermatology, University of Pisa, Pisa, Italy (Drs M. Romanelli and Dini); and Department of Dermatology and Cutaneous Surgery, University of Miami, Miami, Florida (Dr P. Romanelli).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

A Case Report of the Eradication of Pseudomonas aeruginosa from Leg Ulcer in a Patient with Essential Thrombocythemia
Savini et al.
INT J LOW EXTREM WOUNDS 2009;8:117-119.
ABSTRACT