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Implications for Treatment

Sulochana S. Bhandarkar, MD; Cynthia Cohen, MD; Maria Kuruvila, MD; Thomas H. Rea, MD; Jamie B. MacKelfresh, MD; Delphine J. Lee, MD, PhD; Robert L. Modlin, MD; Jack L. Arbiser, MD, PhD

Arch Dermatol. 2007;143(12):1527-1529.

Objective  To examine the potential role of angiogenesis in leprosy.

Design  Immunohistochemical analysis of leprosy lesions.

Setting  Department of Dermatology, Venereology, and Leprology, Kasturba Medical College; Division of Dermatology, University of California at Los Angeles; and Departments of Dermatology and Pathology, Emory University.

Patients  Thirty-two cutaneous lesions that represented the spectrum of leprosy were obtained from 32 patients.

Main Outcome Measure  CD31 microvessel counts.

Results  The mean CD31 microvessel count in borderline tuberculoid, midborderline, and lepromatous leprosy lesions was significantly higher than in indeterminate leprosy lesions.

Conclusions  Increased bacterial load is associated with increased angiogenesis. Angiogenesis inhibitors may be of benefit in the treatment of leprosy.

Author Affiliations: Departments of Dermatology (Drs Bhandarkar, MacKelfresh, and Arbiser) and Pathology (Dr Cohen), Emory University School of Medicine, Atlanta, Georgia; Department of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles (Drs Lee and Modlin); Department of Dermatology, Venereology, and Leprology, Kasturba Medical College, Mangalore, India (Drs Bhandarkar and Kuruvila); and Department of Dermatology, University of Southern California, Los Angeles (Dr Rea).

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