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A Double-blind Randomized Controlled Trial

Rachel Wenner, MD; Sharone K. Askari, MD; Peter M. H. Cham, MD; Deborah A. Kedrowski, RN; An Liu, MS; Erin M. Warshaw, MD, MS

Arch Dermatol. 2007;143(3):309-313.

Objective  To evaluate the efficacy of duct tape occlusion therapy for the treatment of common warts in adults.

Design  Double-blind controlled clinical intervention trial.

Setting  Veterans Affairs medical center.

Participants  A total of 90 immunocompetent adult volunteers with at least 1 wart measuring 2 to 15 mm were enrolled between October 1, 2004, and July 31, 2005. Eighty patients completed the study.

Intervention  Patients were randomized by a computer-generated code to receive pads consisting of either moleskin with transparent duct tape (treatment group) or moleskin alone (control group). Patients were instructed to wear the pads for 7 consecutive days and leave the pad off on the seventh evening. This process was repeated for 2 months or until the wart resolved, whichever occurred first. Follow-up visits occurred at 1 and 2 months.

Main Outcome Measure  Complete resolution of the target wart. Secondary outcomes included change in size of the target wart and recurrence rates at 6 months for warts with complete resolution.

Results  There were no statistically significant differences in the proportions of patients with resolution of the target wart (8 [21%] of 39 patients in the treatment group vs 9 [22%] of 41 in the control group). Of patients with complete resolution, 6 (75%) in the treatment group and 3 (33%) in the control group had recurrence of the target wart by the sixth month.

Conclusion  We found no statistically significant difference between duct tape and moleskin for the treatment of warts in an adult population.

Trial Registration  clinicaltrials.gov Identifier: NCT00328991

Author Affiliations: Departments of Dermatology, University of Minnesota, Minneapolis (Drs Wenner and Warshaw) and Saint Louis University, St Louis, Mo (Dr Askari), and Dermatology Section (Drs Wenner, Cham, and Warshaw and Ms Kedrowski) and Centers for Chronic Disease Outcomes and Research (Ms Liu), Minneapolis Veterans Affairs Medical Center, Minneapolis.

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