 |
 |

Correlation of Dermoscopy With In Vivo Reflectance Confocal Microscopy of Streaks in Melanocytic Lesions
Alon Scope, MD;
Melissa Gill, MD;
Cristiane Benveuto-Andrade, MD;
Allan C. Halpern, MD;
Salvador Gonzalez, MD, PhD;
Ashfaq A. Marghoob, MD
Arch Dermatol. 2007;143(6):727-734.
Objective To analyze dermoscopically identified streaks by direct correlation with features visualized on reflectance confocal microscopy (RCM).
Design We evaluated by RCM melanocytic lesions showing peripheral streaks on dermoscopy. A digital camera connected to the RCM computer enabled direct analysis of the streaks. The lesions were excised and histopathologically analyzed.
Setting Dermatology clinic specializing in pigmented lesions.
Patients The study population comprised 7 patients with melanocytic lesions, including 2 melanomas, 4 dysplastic nevi, and 1 compound nevus with spitzoid features.
Results In 6 of the cases, peripheral streaks were visualized on RCM as confluent aggregates composed of bright, ill-demarcated cells. These aggregates were contiguous with the bright central part of the lesion and appeared to be curving around dermal papillae. Of the 6 lesions, 3 with elongated aggregates visualized on RCM harbored peripheral, elongated nests on histopathologic examination, and 2 with shorter, more ill-defined peripheral aggregates visualized on RCM had smaller, more poorly formed peripheral nests on histopathologic examination. The seventh lesion showed few peripheral streaks on dermoscopy; however, corresponding features visualized on RCM showed discrete, dense, round nests aligned in proximity. We did not recognize in the present series distinguishing characteristics on RCM that could differentiate between the peripheral streaks of malignant melanoma and nevi.
Conclusions Direct dermoscopy-RCM correlation is a feasible method to study streaks and may help to improve the classification methods used in dermoscopy. Additional studies with larger series are needed to confirm our findings and may help elucidate the morphologic and biological nature of peripheral streaks.
Author Affiliations: Dermatology Service, Department of Medicine (Drs Scope, Benveuto-Andrade, Halpern, Gonzalez, and Marghoob), and Department of Pathology (Dr Gill), Memorial Sloan-Kettering Cancer Center, New York, NY.
CiteULike Connotea Del.icio.us Digg Reddit Technorati Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
In Vivo Confocal Microscopic and Histopathologic Correlations of Dermoscopic Features in 202 Melanocytic Lesions
Pellacani et al.
Arch Dermatol 2008;144:1597-1608.
ABSTRACT
| FULL TEXT
Remodeling of the Dermoepidermal Junction in Superficial Spreading Melanoma: Insights Gained From Correlation of Dermoscopy, Reflectance Confocal Microscopy, and Histopathologic Analysis
Scope et al.
Arch Dermatol 2008;144:1644-1649.
FULL TEXT
|