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A Mayo Clinic 5-Year Retrospective Review, January 1, 2001, Through December 31, 2005

Mark D. P. Davis, MD; Leigh Ann Scalf, MD; James A. Yiannias, MD; Janet F. Cheng, MD; Rokea A. el-Azhary, MD; Audrey L. Rohlinger, BS; Sara A. Farmer, BA; Debra D. Fett, MD; Janis S. Johnson, RN; Diane L. Nordberg Linehan, RN; Donna M. Richardson, RN; Arnold L. Schroeter, MD; Suzanne M. Connolly, MD

Arch Dermatol. 2008;144(1):67-72.

Objective  To present and interpret results of patch testing with the Mayo Clinic standard series over 5 years.

Design  Retrospective study. A standardized patch testing technique was used. Data were recorded on a standardized computer program from January 1, 2001, to December 31, 2005, and analyzed.

Setting  Tertiary referral center.

Patients  Patients who were referred for patch testing.

Intervention  Patch testing with the "standard series," ie, a standard series of allergens used by most clinicians to identify the most common offending allergens in patients with allergic contact dermatitis.

Main Outcome Measures  Number of patients patch tested, allergens used over this period, and rates of allergic patch test reactions to allergens.

Results  A total of 3854 patients (mean age, 55.1 years; age range, 6.2-99.4 years; 2576 female [66.8%]) were tested. All dermatologists in the department performed patch testing. The mean number of allergens included was 69.3 (range, 6-87). There were 2664 patients with at least 1 positive reaction (69.1%) and 1933 with 2 or more positive reactions (50.2%). Metals, fragrances, topical antibiotics, preservatives, and individual allergens used in hair-care products, topical corticosteroids, glues, plastics, and rubber were still the most common allergen groups associated with allergic patch test reactions.

Conclusions  We describe the structure of the patch testing service at our referral center. Ongoing analysis of our patch test reaction rates allows us to recommend broad, clinically relevant, and up-to-date allergens for testing.

Author Affiliations: Mayo Clinic Contact Dermatitis Group, Department of Dermatology (Drs Davis, Scalf, el-Azhary, Fett, and Schroeter and Ms Richardson) and Division of Biostatistics (Mss Rohlinger and Farmer), Mayo Clinic, Rochester, Minnesota; Department of Dermatology (Drs Yiannias and Connolly and Ms Johnson), Mayo Clinic, Scottsdale, Arizona; and Department of Dermatology (Dr Cheng and Ms Nordberg Linehan), Mayo Clinic, Jacksonville, Florida.