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Yi-Ju Chen, MD; Chun-Ying Wu, MD, PhD, MPH; Jui-Lung Shen, MD; Szu-Ying Chu, MD; Chih-Kang Chen, MD; Yun-Ting Chang, MD, PhD; Chuan-Mu Chen, PhD

Arch Dermatol. 2008;144(12):1571-1575.

Objective  To evaluate the role of leptin, a 16-kDa adipocyte-derived hormone, in the development of metabolic dysregulation of psoriasis.

Design  Case-control study.

Setting  Referral centers.

Patients  Seventy-seven patients with psoriasis and 81 age- and sex-matched control subjects were included in the study.

Intervention  Enzyme-linked immunoassay of serum samples from study subjects.

Main Outcome Measures  Serum leptin levels and proportions of comorbidities (including hypertension, diabetes mellitus, metabolic syndrome, hypertriglyceridemia, and reduced high-density lipoprotein cholesterol concentrations) in cases vs controls were compared using ² and Mann-Whitney tests. The clinical significance of leptin in psoriasis was analyzed using logistic regression models.

Results  Significantly more obesity (odds ratio [OR], 2.67) and hypertension (2.17) (P =.04 for both) were observed in subjects with psoriasis. High serum leptin levels (7397.43 pg/mL) were found in female subjects (OR, 6.05; P < .001) and in subjects with obesity (3.45; P =.01), hypertension (2.19; P =.04), metabolic syndrome (3.58; P =.008), and psoriasis (2.25; P =.02). On multivariate analysis, psoriasis (OR, 4.57; P =.009) was significantly associated with hyperleptinemia independent of female sex (26.36; P < .001), metabolic syndrome (4.37; P =.04), and obesity (2.83; P =.12). Finally, patients with psoriasis who had hyperleptinemia tended to be female (P < .001) and manifested obesity (P =.002) and metabolic syndrome (P =.003).

Conclusions  Hyperleptinemia is associated with psoriasis independent of female sex and other conventional cardiovascular risk factors such as obesity and metabolic syndrome. Hyperleptinemia in psoriasis may contribute to metabolic syndrome.

Author Affiliations: Departments of Dermatology (Drs Y.-J. Chen and Shen) and Gastroenterology (Dr Wu), Taichung Veterans General Hospital, Department of Life Sciences, National Chung Hsing University (Drs Y.-J. Chen and C.-M. Chen), and College of Public Health, China Medical University (Dr Wu), Taichung; Departments of Dermatology (Drs Y.-J. Chen and Chang) and Internal Medicine (Dr C.-K. Chen), National Yang Ming University, Department of Dermatology, Taipei Veterans General Hospital (Drs Chu and Chang), and Departments of Dermatology, Cardinal Tien Hospital (Dr C.-K. Chen), Taipei, and National Yang Ming University Hospital, I-Lan (Dr Chang), Taiwan.

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