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Brenda Chrastil-LaTowsky, MD; Naissan O. Wesley, MD; Jennifer L. MacGregor, MD; Michael S. Kaminer, MD; Kenneth A. Arndt, MD

Arch Dermatol. 2009;145(11):1309-1312.

Background  Given the recent boom of the cosmetic industry, there is a wealth of new products available to patients and physicians, including soft-tissue fillers. Bio-Alcamid polyacrylamide gel (Polymekon, Milan, Italy) is a filler that has potential to cause adverse reactions.

Observations  Two patients who had previously been treated with Bio-Alcamid outside of the United States presented with different manifestations of inflammatory responses to the product. These reactions were challenging to treat.

Conclusions  Despite claims of safety, Bio-Alcamid and possibly other soft-tissue fillers available worldwide have the potential to cause adverse reactions. Physicians should be aware of the various presentations and treatment options for these reactions.

Author Affiliations: SkinCare Physicians, Chestnut Hill, Massachusetts.

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