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Successful Treatment of Complex Aphthosis With Colchicine and Dapsone
Carrie B. Lynde, HBSc, LLB;
Alison J. Bruce, MD;
Roy S. Rogers III, MD
Arch Dermatol. 2009;145(3):273-276.
Objective To investigate the effectiveness of colchicine and dapsone, 2 corticosteroid-sparing anti-inflammatory agents, in the treatment of patients with complex aphthosis (recurrent oral and genital aphthous ulcers or severe, almost constant, multiple oral aphthae in the absence of Behçet syndrome).
Design Retrospective review of medical records.
Setting Tertiary care medical clinic.
Patients Fifty-five patients with complex aphthosis evaluated and treated at Mayo Clinic between January 1, 1998, and July 31, 2007. All the patients were treated according to a therapeutic ladder, starting with colchicine and adding dapsone to treatment of patients who did not have a substantial response (>75% improvement) to colchicine or who discontinued colchicine use because of adverse effects.
Main Outcome Measures A substantial response to therapy with colchicine alone, dapsone alone, or colchicine and dapsone combined.
Results Most patients (44 [80%]) had a substantial response to therapy and had no serious adverse effects.
Conclusions Colchicine and dapsone are effective, safe therapies for the treatment of complex aphthosis. Colchicine and dapsone, 2 established drugs also used for gout and leprosy, respectively, and for other dermatologic disorders, should be considered efficacious in the treatment of complex aphthosis.
Author Affiliations: Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada (Ms Lynde); and Divisions of Clinical Dermatology (Dr Bruce) and Laboratory Dermatology (Dr Rogers), Mayo Clinic, Rochester, Minnesota. Ms Lynde is a Roy S. Rogers III Scholar, Mayo Clinic.
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