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Report of 2 Cases and Retrospective Study of 18 Patients With Drug-Induced Hypersensitivity Syndrome

Yusuke Asano, MD; Hiroaki Kagawa, MD; Yoko Kano, MD; Tetsuo Shiohara, MD

Arch Dermatol. 2009;145(9):1030-1036.

Background  Overt cytomegalovirus (CMV) disease is a serious viral infection that usually occurs in immunocompromised patients but rarely in immunocompetent patients. Cutaneous lesions, albeit rare, occur as late systemic manifestations of CMV infections and are usually fatal.

Observations  We describe 2 patients with drug-induced hypersensitivity syndrome (one end of a spectrum of severe drug eruptions) who subsequently developed cutaneous CMV ulcers at unusual sites, such as the trunk; this occurrence was immediately followed by gastrointestinal manifestations, which were fatal in 1 patient. To identify factors predictive of CMV disease, we retrospectively investigated the prevalence of CMV reactivation during drug-induced hypersensitivity syndrome in 18 patients. In this analysis, patients were divided into 2 groups depending on the positivity of CMV DNA in the blood.

Conclusions  Older and male patients with antecedent high human herpesvirus 6 DNA loads are at risk for CMV disease irrespective of corticosteroid administration. A rapid reduction in white blood cell numbers is also predictive of the onset of CMV disease.

Author Affiliations: Department of Dermatology, Kyorin University School of Medicine, Tokyo, Japan.

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