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DEREK J. CRIPPS, M.B., B.S. (LOND.), M.S.; ARTHUR C. CURTIS, M.D.

Arch Dermatol. 1962;86(5):575-581.

Abstract
Three patients with porphyria hepatica are reported including I with the mixed type and 2 with porphyria cutanea tarda. The administration of chloroquine, in total doses ranging from 1 to 2.5 gm., resulted in an exacerbation of clinical symptoms by the third or fourth day, manifested by malaise, fever, tachycardia, and impaired liver function. In addition, a considerable disturbance of urinary porphyrins occurred, which was estimated by quantitative studies.

Author Affiliations
ANN ARBOR, MICH.

The Department of Dermatology, The University of Michigan.

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