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  Vol. 86 No. 5, November 1962 TABLE OF CONTENTS
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Method for Comparing Percutaneous Absorption of Steroids

A. W. McKENZIE, M.R.C.P.; R. B. STOUGHTON, M.D.

Arch Dermatol. 1962;86(5):608-610.


Abstract

A simple method for assessing the percutaneous absorption of steroid preparations is suggested.

Using vasoconstriction as an index of absorption, occlusion of the skin surface with Saran Wrap results in a 100-fold difference in absorption over simple topical application.



Author Affiliations

LONDON; CLEVELAND

Fellow in Dermatology (Dr. McKenzie), Western Reserve University; Present address: St. Thomas' Hospital, London S.E.1, England; Director of Dermatology (Dr. Stoughton), Western Reserve University.


Footnotes

Supported by a grant from the Department of Health, Education, and Welfare.



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