This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (189)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

A. W. McKENZIE, M.R.C.P.

Arch Dermatol. 1962;86(5):611-614.

Abstract
The vasoconstrictor effect of various topical steroids applied to protected and occluded skin is described. The method indicates that acetates are better absorbed than the parent alcohol, while the phosphate salts are poorly absorbed. In the case of triamcinolone, the formation of the acetonide leads to greatly enhanced percutaneous absorption. The use of a plastic film over these compounds leads to a 100-fold increase in absorption when compared with simple topical application. Using vasoconstriction as an index of absorption, it is suggested that the method may be of use in determining the penetrability and activity of new compounds.

Author Affiliations
LONDON, ENGLAND

Fellow in Dermatology, Western Reserve University, Cleveland.

Footnotes
Supported in part by a grant from the Department of Health, Education and Welfare.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Transient Effect of Inhaled Fluticasone on Airway Mucosal Blood Flow in Subjects with and without Asthma
KUMAR et al.
Am. J. Respir. Crit. Care Med. 2000;161:918-921.
ABSTRACT | FULL TEXT  

A Double-blind Controlled Comparison of Generic and Trade-Name Topical Steroids Using the Vasoconstriction Assay
Olsen
Arch Dermatol 1991;127:197-201.
ABSTRACT  

Intrinsic Potencies of Novel Thiol Ester Corticosteroids RS-85095 and RS-21314 as Compared With Clobetasol 17-Propionate and Fluocinonide
Ong et al.
Arch Dermatol 1989;125:1662-1665.
ABSTRACT  

Are Generic Formulations Equivalent to Trade Name Topical Glucocorticoids?
Stoughton
Arch Dermatol 1987;123:1312-1314.
ABSTRACT  

Topically Applied Fluocinonide in an Adhesive Base in the Treatment of Oral Vesiculoerosive Diseases
Lozada and Silverman
Arch Dermatol 1980;116:898-901.
ABSTRACT  

Clinical Effect of Aerosol Triamcinolone Acetonide in Bronchial Asthma
Grieco et al.
Arch Intern Med 1978;138:1337-1341.
ABSTRACT  

Tachyphylaxis to Topically Applied Steroids
du Vivier
Arch Dermatol 1976;112:1245-1248.
ABSTRACT  

Topical Photosensitizers: Influence of Vehicles on Penetration
Kaidbey and Kligman
Arch Dermatol 1974;110:868-870.
ABSTRACT  

Topical Corticosteroid Therapy: Efficacy of Frequent Application
Eaglstein et al.
Arch Dermatol 1974;110:955-956.
ABSTRACT  

Paired Comparison Vasoconstrictor Assays: A Comparison of Methods for the Determination of Relative Vasoconstrictor Potency of Topically Applied Corticosteroids
Poulsen et al.
Arch Dermatol 1974;109:367-371.
ABSTRACT  

Bioassay System for Formulations of Topically Applied Glucocorticosteroids
Stoughton
Arch Dermatol 1972;106:825-827.
ABSTRACT  

Extemporaneous Formulation Of Topical Corticosteroids
Caldwell
JAMA 1970;212:1963-1963.
ABSTRACT  

Vasoconstrictor and Systemic Activities of Topical Steroids
Child et al.
Arch Dermatol 1968;97:407-410.
ABSTRACT  

Betamethasone 17-Valerate: A Custom-Made Topical Corticosteroid
Zimmerman
Arch Dermatol 1967;95:514-519.
ABSTRACT  

Mediators of Inflammation
STOUGHTON
Arch Dermatol 1966;93:601-607.
ABSTRACT  

Human and Animal Anti-Inflammatory Activity of an Acetonide of Progesterone: Dichotomy of Results Between Man and Laboratory Animal with 16, 17-Dihydroxyprogesterone Acetonide
BRONSTEIN et al.
Arch Dermatol 1966;93:114-118.
ABSTRACT  

Penetration of 14C Hydrocortisone Through Normal Skin: The Effect of Stripping and Occlusion
FELDMANN and MAIBACH
Arch Dermatol 1965;91:661-666.
ABSTRACT  

Topical Activities of Betamethasone Esters in Man
McKENZIE and ATKINSON
Arch Dermatol 1964;89:741-746.
ABSTRACT  

A Hazard of Plastic Film Therapy
VICKERS and FRITSCH
Arch Dermatol 1963;87:633-636.
ABSTRACT