This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Study of a Large Family

DONALD C. ABELE, MD; RICHARD L. DOBSON, MD; JOHN B. GRAHAM, MD

Arch Dermatol. 1963;88(1):38-47.

Abstract
The mode of inheritance of psoriasis in a large North Carolina kindred proved to be that of simple autosomal dominance with penetrance reduced to about 60%.

No association was found between serum levels of uric acid and cholesterol and the occurrence of psoriasis in this kindred.

The incidence of arthritis was 2.7% in the kindred, and there was no greater incidence among the psoriatic members of this kindred than the nonpsoriatic members.

Rheumatoid factor was not detected in either the arthritic or nonarthritic members of this kindred by the latex agglutination technique.

It is suggested that mutation at more than one locus and/or multiple alleles at the "psoriasis" locus may account for the conflicting reports concerning the inheritance of psoriasis.

Author Affiliations
CHAPEL HILL, NC

From the Departments of Medicine and Pathology, University of North Carolina School of Medicine.

Instructor in Medicine (Dermatology), University of North Carolina School of Medicine (Dr. Abele); Associate Professor of Dermatology, University of Oregon School of Medicine, Portland, Ore (Dr. Dobson); and Professor of Pathology, University of North Carolina School of Medicine (Dr. Graham).

Footnotes
This investigation was supported (in part) by a research grant (H-3140) from the National Institutes of Health.

CiteULike    Connotea    Del.icio.us    Digg    Facebook    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Cyclosporine in Psoriasis Treatment: Inhibition of Keratinocyte Cell-Cycle Progression in G1 Independent of Effects on Transforming Growth Factor {alpha}/Epidermal Growth Factor Receptor Pathways
Khandke et al.
Arch Dermatol 1991;127:1172-1179.
ABSTRACT  

The Genetics of Psoriasis: Haplotype Sharing in Siblings With the Disease
Suarez-Almazor and Russell
Arch Dermatol 1990;126:1040-1042.
ABSTRACT  

HLA Region Genes and Immune Activation in the Pathogenesis of Psoriasis
Gottlieb and Krueger
Arch Dermatol 1990;126:1083-1086.
ABSTRACT  

Ichthyosiform Dermatoses: Classification Based on Anatomic and Biometric Observations
FROST and VAN SCOTT
Arch Dermatol 1982;118:846-859.
ABSTRACT  

The Inheritance of Psoriasis
Dobson
Arch Dermatol 1980;116:657-657.
ABSTRACT  

Trizygotic Triplets and Dizygotic Twins in a Family With Psoriasis
Cutler et al.
Arch Dermatol 1980;116:718-719.
ABSTRACT  

The Genetics of Psoriasis
Watson et al.
Arch Dermatol 1972;105:197-207.
ABSTRACT  

Ichthyosiform Dermatoses: Classification Based on Anatomic and Biometric Observations
FROST and VAN SCOTT
Arch Dermatol 1966;94:113-126.
ABSTRACT  

Chromosome Studies of Normal and Psoriatic Skin Fibroblasts
HOCHGLAUBE and KARASEK
Arch Dermatol 1965;92:195-199.
ABSTRACT