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CALVIN J. DILLAHA, MD; G. THOMAS JANSEN, MD; W. MAGE HONEYCUTT, MD; A. CALVIN BRADFORD, MD

Arch Dermatol. 1963;88(3):247-256.

Abstract
As an investigative procedure, a hydrophilic ointment containing 20% 5-fluorouracil (5-FU) was applied to the skin of patients with extensive actinic keratoses of the face and neck, for a period of four weeks. This resulted in a selective inflammation, erosion, and disappearance of the keratoses without significant alteration of the normal skin. Transitory adverse reactions included corneal and conjunctival irritations, phototoxic reactions, and erosion of the lower lip border. No evidence of systemic absorption was detected. Only preliminary follow-up observations are available, and no conclusion can be drawn as to the long-term results.

Author Affiliations
LITTLE ROCK, ARK

From the Division of Dermatology, Department of Medicine, School of Medicine and Clinical Research Center, University of Arkansas and from the Little Rock Veterans Administration Hospital.

Footnotes
This investigation was supported in part by Public Health Service Grant FR-49 from the Division of Research Facilities and Resources.

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